1,5-Hydride-Shift-Triggered Cyclization for the Synthesis of Unsymmetric Julolidines
SYNTHESIS-STUTTGART(2021)
Abstract
Directly accessible 8-substituted tetrahydroquinolines undergo 1,5-hydride-shift-triggered cyclization to provide difficult to access julolidine derivatives in yields of 21-98% under scandium(III) triflate catalysis. Additionally, the scope of the reaction, several follow-up transformations and a remarkable side process discovered during optimization of the conditions are highlighted.
MoreTranslated text
Key words
julolidine, 1,5-hydride shift, redox-neutral reaction, tetrahydroquinoline, catalysis
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined