Redox-Neutral Nickel-Catalyzed Cross-Coupling Reactions Of (Homo)Allylic Alcohols And Aryltriflates
ACS CATALYSIS(2021)
摘要
Herein, we report a redox-neutral Ni-catalyzed cross-coupling reaction of two readily available precursors to produce the corresponding ketones that are an important structural motif in numerous biologically active entities. By the use of a commercially available nickel/Triphos catalytic system, a range of easily accessible alkenyl primary alcohols and aryltriflates can be converted in a rapidly assembled fashion to valuable ketones with good yields and wide functional group tolerance. We also demonstrate the utility of this transformation by late-stage functionalization of a large set of complex molecules with good efficiency, which offers a distinct entry to more functionalized aromatic ketones.
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关键词
nickel catalysis, isomerization, ketone, cross-coupling, redox-neutral transformation
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