Electricity-induced micro-flow C-H/N-H alkyne annulation: a greener approach to access heteroaromatic compounds

Fast access to structurally diverse heteroaromatic compounds is demonstrated in an integrated continuous-flow manner without employing any expensive oxidant. The process involves an electro-flow heating reactor that uses electricity as the green oxidant to promote the reaction, leading to a fast (2 min) annulation reaction for the synthesis of heteroaromatic compounds.