N-Heterocyclic carbene-catalyzed radical ring-opening acylation of oxime esters with aldehydes
ORGANIC CHEMISTRY FRONTIERS(2021)
Abstract
A cross-coupling of cycloketone oxime esters with aldehydes catalyzed by N-heterocyclic carbenes via a radical pathway was established. This modular protocol features easy operation, no external oxidants or reductants, and a broad functional group compatibility. The merit of this method was showcased by late-stage modification of complicated aldehydes derived from the medical intermediate pregnenolone and natural product diacetone-d-glucose.
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Key words
N-Heterocyclic Carbenes,Oxidative Coupling,Organocatalysis,Homogeneous and Heterogeneous Catalysis
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