Cardioprotective Effect Of All-Trans Retinoic Acid On Cisplatin Induced Cardiotoxicity In Rats

Purpose: Cisplatin (CP) is an antineoplastic agent widely used in the treatment of various tumors. Retinoic acid has potent antioxidant effects. In this study, it is aimed to reveal the effects of all-trans retinoic acid (ATRA) on CP induced cardiotoxicity.Materials and Methods: In the study, wistar albino rats were used. Control group received single daily doses of 1 ml/kg saline and ATRA group received single daily doses of ATRA(7,5mg/kg/day) intraperitoneally (i.p.) for 10 days. ATRA+CP group received a single dose of CP(7mg/kg) i.p. on the fourth day of the 10 days of ATRA (7,5mg/kg/day) i.p. treatment. The rats in the CP group received only a single dose of cisplatin(7mg/kg) i.p. given on the 4th of 10 days of treatment. After treatment, the groups were compared based on cardiac histopathology findings.Results: Necrosis, cytoplasmic vacuolization, congestion, hemorrhage and edema were more common in the CP group than the control group). Necrosis and cytoplasmic vacuolization in the all-trans retinoic acid + cisplatin group was observed statistically significantly less frequently than the CP group.Conclusion: This study confirmed that cisplatin therapy had destructive effects on heart tissue, and showed that all-trans retinoic acid treatment could histopathologically prevent cisplatin-induced cardiotoxicity.