Tg-Dta Of Inclusion Compound Consisting Of Acetaminophen Incorporated Into 1d Nanochannels Of 2,4,6-Tris(4-Chlorophenoxy)-1,3,5-Triazine

Inclusion compounds (ICs) have the potential to act as drug carriers. In this study, an IC consisting of acetaminophen incorporated into 2,4,6-tris(4-chlorophenoxy)-1,3,5-triazine (CLPOT) was synthesized ([CLPOTacetaminophen]). Elemental analysis, H-1 NMR spectroscopy and thermogravimetry-differential thermal analysis (TG-DTA), of the IC confirmed that similar to 0.1 acetaminophen molecules were included as guest molecules per CLPOT unit cell. The inclusion of acetaminophen in the 1D nanochannels of CLPOT was further confirmed by the DTA results of [CLPOT-acetaminophen], which showed the endothermal peak at 157 degrees C indicating the desorption of acetaminophen confined in the CLPOT nanochannels. These results suggest that CLPOT could be used as a stable microscopic carrier of biomaterials.