Antioxidant Activity Of Some N-3 Substituted Thiazolo[4,5-B]Pyridines

A series of N-3 substituted 5,7-dimethyl-3H-thiazolo[4,5-b]pyridine-2-ones were synthesized by reaction [3+3]coclocondensation,alkylation, hydrazinolysis, and under the reaction of nucleophilic addition with subsequent cleavage utilization. The antioxidant activity of thiazolo[4,5-b]pyridine-2-one derivatives was evaluated in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. The identified antioxidant activity among thiazolo[4,5-b]pyridines. When compared with existing antioxidants, some of our compounds were found to be more potent.