Toxicological and Pharmacological Studies of a Crystal Structure Derivative of 8-Hydroxyquinoline

In this work, we carried out the evaluation of the toxicity, the anxiogenic effect and the antidepressant activity by intraperitoneal administration of the compound “5-(((2-hydroxy-ethyl)thio)methyl)quinolin-8-ol)quinoline-8-ol.” The anxiogenic effect was achieved by simple and effective texts already described in the literature such as open field test and elevated plus-maze test, while the antidepressant activity was carried out by performing the forced swimming test. To carry out this study, we have chosen, therefore, to use five groups of adult rats and each group contains five rats. The results obtained from this study show that this new compound derivative of 8-hydroxyquinoline does not show signs of toxicity, anxiety and depression before the lethal dose of 100 mg/kg (LD50 = 100 mg/kg), and by consequently, this compound is likely to present very important biological activity for a possible pharmaceutical and medicinal use at low doses (< 100 mg/kg).