Oral Helicobacter Pylori (Hp) Is Correlated With The Occurrence Of Periodontitis

Objective: To investigate the effect of Helicobacter pylori (Hp) on periodontitis dominant bacteria and define the importance in clearing oral Hp for removal of gastric Hp and good periodontal health. Methods: In total, 320 patients (40 +/- 20 years old) received C-13 breath test to treat digestive tract symptoms. The correlation between Hp infection and periodontitis by rapid oral urease test were investigated. They were divided into Hp Positive and Negative groups. Meanwhile, 42 periodontitis patients who were oral Hp negative were selected as the control subjects. The correlation between Pg (Porphyromonas gingivalis), Pi (Periodontitis pathogen), Bf (Bacteroides forsythus) amount and oral Hp infection was determined. There were 30 patients experiencing crown lengthening surgery without alveolar ridge crest absorption that were screened with periapical film. After root canal therapy, gingival tissue was removed for TUNEL test. The epithelial apoptosis indexes were compared. Results: Oral Hp positive rate was 68.75%. The oral Hp positive rates in periodontitis groups (PG) were higher than that in NPG. However, it did not increase with the severity of periodontal disease. Gastric Hp infection was an important factor of oral Hp infection. Oral Hp was positively correlated with the expression of Pg and Pi. The oral Hp positive rate in the NPG was 40%. Apoptosis staining was observed in gingival epithelial cells of patients. These patients needed to receive crown lengthening due to crown fracture. However, the index in the Hp infection group was higher (P < 0.05). Conclusions: Oral Hp infection is closely related to gastric Hp infection. The expression rate of oral Hp in patients with periodontitis increases. The deep periodontal pocket environment of severe periodontitis propotes Hp proliferation. Oral Hp can copolymerize with the periodontal Pg and Pi. The occurrence and development of periodontitis is indirectly promoted. Hp promotes apoptosis in periodontal tissue. It may have direct effects on the development of periodontitis.