Spatially-Enhanced Time-Domain Nirs For Determination Of Optical Properties In Layered Structures

Lin Yang,Pranav Lanka,Heidrun Wabnitz,Rinaldo Cubeddu,Thomas Gladytz,Sanathana Konugolu Venkata Sekar,Dirk Grosenick,Antonio Pifferi,Rainer Macdonald

DIFFUSE OPTICAL SPECTROSCOPY AND IMAGING VII（2019）

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摘要

A multivariate method integrating time-domain and space-domain techniques of near-infrared spectroscopy is proposed for simultaneously retrieving the absolute quantities of optical scattering and absorption properties in tissues. The concept is theoretically demonstrated by Monte-Carlo simulations in the homogenous case, and then applied on two-layer liquid phantoms. The deviations from nominal values are typically less than 6% for absorption coefficients in both layers

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关键词

Time-domain diffuse optical spectroscopy, Spatially resolved near-infrared spectroscopy, Tissue-like phantoms, Numerical regularization

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