In Vivo Time Domain Speckle Contrast Optical Spectroscopy

M. Pagliazzi,E. E. Vidal-Rosas,S. Konugolu Venkata Sekar,L. Di Sieno,L. Colombo,D. Contini,A. Torricelli,A. Pifferi,A. Dalla Mora,J. P. Culver,T. Durduran

DIFFUSE OPTICAL SPECTROSCOPY AND IMAGING VII（2019）

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摘要

We propose a time domain speckle contrast optical spectroscopy (SCOS) system that makes use of a gated detector and pulsed light source to measure the blood flow variations at very short, quasi-null (<3mm) source-detector separation. We present the results of a human arm cuff occlusion and a comparison with standard SCOS, highlighting that we can probe deeper into tissue, reduce probe footprint, make efficient use of the signal and decrease cost.

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关键词

Time-resolved imaging, speckle imaging, spectroscopy, speckle

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