Human Solid-Phase Gastric-Emptying Measurement By Ams Using C-14 Tracer

Determining solid-phase gastric emptying (GE) in a human being is an important application in clinical practice as it can provide valuable information for the diagnosis of related digestive diseases. Currently, Tc-99m gastric scintigraphy is considered as the gold standard for measuring GE. However, this method suffers from clinical drawback, such as radiation exposure. This study focuses on identifying alternative methods for GE measurement. Carbon-14 accelerator mass spectrometry (AMS) is a useful tool for biomedical projects due to its inherently high sensitivity and dynamic range, low dose and sample size requirements, and relatively short measurement time. However, it has not yet been implemented in GE tests. In this work, C-14 AMS methodology was developed for breath samples. Measurements were conducted on a compact, single-stage AMS device at China Institute of Atomic Energy (CIAE). To investigate GE, micro-doses of C-14-octanoic acid, C-13-octanoic acid, and Tc-99m were marked along with tracers in the same test meal and subsequently ingested by volunteers. The C-14-octanoic acid breath test (C-14-OBT) in combination with AMS showed better counting statistics than those obtained for the C-13-OBT measured using infrared spectroscopy. The results also demonstrate a considerably lower radiation dose than that in Tc-99m gastric scintigraphy. This work establishes an alternative method of C-14-AMS tracing to determine solid-phase GE in a human being, which could provide clinical technical support for a GE test and further expand the range of C-14-AMS applications in biomedicine.