Stereocontrolled Synthesis Of Alpha-Amino-Alpha '-Alkoxy Ketones By A Copper-Catalyzed Cross-Coupling Of Peptidic Thiol Esters And Alpha-Alkoxyalkylstannanes
ORGANIC LETTERS(2011)
摘要
A stereocontrolled synthesis of alpha-amino-alpha'-alkoxy ketones is described. This pH-neutral copper(I) thlophene-2-carboxylate (CuTC)-catalyzed cross-coupling of amino acid thiol esters and chiral nonracemic alpha-alkoxyalkylstannanes gives alpha-amino-alpha'-alkoxy ketones in good to excellent yields with complete retention of configuration at the alpha-amino- and alpha-alkoxy-substituted stereocenters.
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关键词
peptidic thiol esters,ketones,synthesis,copper-catalyzed,cross-coupling
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