Brønsted acid and Lewis acid co-promoted cascade cyclization reaction and application to the total synthesis of Erysotramidine

Xiaolin Ju,Xiaojun Hu,Hongliang Shi,Shiqiang Ma,Feifei He,Xiaolei Wang,Xingang Xie,Xuegong She

Organic Chemistry Frontiers（2021）

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摘要

A Bronsted acid and Lewis acid co-promoted cascade cyclization reaction was developed for the concise synthesis of disubstituted pyrrolo [2,1-a] isoquinolines. The developed method was also successfully applied to the total synthesis of erythrina alkaloid Erysotramidine.

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