A data-driven approach for the detection of internal standard outliers in targeted LC-MS/MS assays
Journal of Mass Spectrometry and Advances in the Clinical Lab(2021)
摘要
•Identifying internal standard outliers in clinical mass spectrometry assays is imperative.•Current approaches for identifying outliers are arbitrary and do not account for assay drift.•A robust modelling strategy allows laboratories to define their own acceptance criteria from their own data.•This strategy is easily implemented and the code is freely available.
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关键词
Internal standard,Quality control,Mixed-effects models,LC-MS/MS
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