Changes In Antigen-Presenting (Langerhans) Cells Of Oral Mucosa In Patients With Hpv Infection

Despite the fact that HPV infection is widespread among the population around the world, more than 150 strains of HPV viruses are known. At the present stage it is still unclear, why HPV-associated oral papillomas in dental patients either spontaneously undergo involution or become malignant. We investigated the quantitative dynamics of Langerhans cells depending on localization in the structure of such papillomas: in the peripapillary space, in the tissue of the oral mucosa in the presence of HPV infection, without a clinical picture of papillomas and in healthy tissue. It has been established that with long-term existing papillomas, antigen presentation is disturbed, and Langerhans cells can be an indicator of papilloma malignancy.