Solubility Measurement And The Correlation Of Cilostazol In Pure And 1,4-Dioxane + Ethanol Binary Solvents From T=273.15 To 313.15 K

Cilostazol is a neutral molecule with poor solubility. In this work, the solubility data of cilostazol in 10 pure and 1,4-dioxane + ethanol binary solvents was measured using the isothermal saturation method within the temperature range from 273.15 to 313.15 K at atmospheric pressure. In the 10 pure solvents, the results indicated that the maximum and minimum solubility of cilostazol appeared in 1,4-dioxane and isopropanol, respectively. The sequence of solubility was 1,4-dioxane > 2-butanone > acetone > 1-butanol > acetonitrile > methanol > n-propanol > ethanol > ethyl acetate > isopropanol. In a mixture of 1,4-dioxane + ethanol, it first increased and then decreased with increasing mass fraction of 1,4-dioxane in 1,4-dioxane + ethanol mixtures at all selected temperatures. The dissolution process of cilostazol was analyzed by the solvent properties. Moreover, the solubility data of cilostazol in the 10 pure solvents was correlated with the modified Apelblat and lambda h equations. The result in binary mixture at various temperatures was evaluated by the Jouyban-Acree model. In a pure solvent, the RAD values between the experimental and calculated data with modified Apelblat and lambda h equations were all no larger than 3.57 X 10(-2) and 11.40 X 10(-2), respectively. In 1,4-dioxane + ethanol binary mixtures, the RAD data of the Jouyban-Acree model was 6.22 x 10(-2). The study of the dissolution process for cilostazol is an important aspect of its purification and recrystallization.