Pharmacodynamic Considerations In Critically Ill Patients

Sepsis and related changes lead to an array of physiological changes in critically ill patients. As with all other interventional measures, early and appropriate antibiotic regimen is important for control of sepsis-related changes. Antibiotic dosing based on the information from less severely patients results in suboptimal dosing. Therefore, it is important to consider ICU patients as a separate cohort for drug dosing. It is important to understand the variability and quantitatively determine doses required to improve clinical and microbiological outcomes.