The Follow-Up Of Dysplasias Diagnosed By The Fluorescence Bronchoscopy

Our aim was to assess natural history of bronchial squamous dysplasia detected by fluorescence bronchoscopy, that is, which dysplasia has potential to progress to invasive cancer. We could periodically follow up dysplasias detected by fluorescence bronchoscopy, and were subjects of this study. We assessed the correlation among histological outcome and smoking status during the follow-up period, and telomerase activity, Ki-67 labeling index, and p53 immunoreactivity of initial biopsy specimens. Some of dysplasias developed to squamous cell carcinoma, some maintained dysplasias, and another regressed to normal bronchial epithelium. Dysplasia with high telomerase activity, increased Ki-67 labeling index, and p53 positive immunoreactivity tends to remain dysplasia, and have potential to progress to invasive cancer.