Synthesis and antimicrobial activities of new thiosemicarbazones and thiazolidinones in indole series

New thiosemicarbazones were synthesized in excellent yield reaction of indole derivatives with thiosemicarbazides. These thiosemicarbazones were reacted with ethyl bromoacetate to produce original heterocyclic-substituted indole derivatives possessing a 4-oxo-thiazolidine group. Analytical IR and NMR spectra and elemental analysis were performed to reveal their structures. The antimicrobial activity of all synthesized compounds was evaluated for antibacterial activity in vitro against Gram-positive and Gram-negative bacteria. Antibacterial screening data showed that two compounds demonstrated activity against Staphylococcus aureus , Escherichia coli , and Pseudomonas aeruginosa . These preliminary results indicate that some of these newly synthesized compounds show a promising antibacterial potency . Graphic abstract