F-19-detected dual-optimized inverted (1)J(CC) 1,n-ADEQUATE

Modification of the recently reported F-19-detected 1,1-ADEQUATE experiment that incorporates dual-optimization to selectively invert a wide range of (1)J(CC) correlations in a 1,n-ADEQUATE experiment is reported. Parameters for the dual-optimization segment of the pulse sequence were modified to accommodate the increased size of (1)J(CC) homonuclear coupling constants of poly- and perfluorinated molecules relative to protonated molecules to allow broadband inversion of the (1)J(CC) correlations. The observation and utility of isotope shifts are reported for the first time for 1,1- and 1,n-ADEQUATE correlations.