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449P Homologous recombination repair gene mutations predict the efficacy of immune checkpoint inhibitors therapy in colorectal cancer

Y. Lin, J. Zhang,X. Liao, Y. Zhang,M. Luo,Q. Li,M. Xie, C. Liang, S. Liao,Y. Zheng,X. Hu,M. Huang,R. Liang, Y. Li

ANNALS OF ONCOLOGY（2021）

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Abstract
Homologous recombination repair (HRR) genes were known to predict response to immune checkpoint inhibitors (ICI) therapy in patients with advanced non-small cell lung cancer. However, whether HRR mutations are robustly predictive of a clinical benefit of ICI therapy for colorectal cancer (CRC) patients is not clear.
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Key words
immune checkpoint inhibitors therapy,immune checkpoint inhibitors,colorectal cancer
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