Prognostic Impact Of Immune Interactions In Her2+And Triple-Negative Breast Cancer Brain Metastases

G. Griguolo,A. Tosi,M. V. Dieci,S. Fineberg, A. Ventura,M. Bottosso,L. Bauchet,F. Miglietta, J. Jacob,V. Rossi,V. Rigau,W. Jacot,P. F. Conte,A. Rosato,A. Darlix, V. Guarneri

ANNALS OF ONCOLOGY（2021）

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Abstract

Despite clinical implications, the complexity of immune microenvironment in breast cancer (BC) brain metastases (BM) is still poorly understood. Multiplex immunofluorescence (mIF) simultaneously visualizes several IF labeled proteins while maintaining spatial information and can be used to identify spatially interacting cells, potentially providing useful information to guide therapeutic approaches.

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Key words

breast cancer,immune interactions,her2+,triple-negative

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