32P Observational study to compare in vitro sensitivity to therapy in patients-derived organoids (PDOs) with real life outcome: The ChemoSenPDO study

J. Garcias-Donas, Z. Dantes, B. Jimenez, M. Yague,A. Manjunath,L. Ferreira, B. Hefel, J. Slawska,J. F. Rodriguez-Moreno,E. Sevillano,A. Barquin, M. Dorta Suarez, J. Rodriguez Pascual, C. Millan, I. Lopez, L. Jimenez, A. Mueller, M. Barba, S. Ruiz-Llorente,P. Navarro

Annals of Oncology（2021）

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Abstract

Despite recent advances in precision oncology, the majority of cases do not present druggable alterations. In such a scenario, treatments must be selected empirically with the only support of general guidelines. Functional tests, able to interrogate the in vitro sensitivity to different drugs of a tumor could help to rationalize this decision.

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Key words

organoids,chemosenpdo study,pdos,vitro,patients-derived

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