Altered Short- And Long-Range White Matter Fiber Tract Interactions In Major Depressive Disorder

Studies of diffusion-weighted magnetic resonance imaging have demonstrated altered structural connectivity within major white matter (WM) fiber tract pathways in major depressive disorder (MDD) patients. Here, we use a novel connectomics approach to investigate how long-range and short-range connectivity between major fiber tracts in MDD patients differ from those in the healthy controls (HC), based on a new measure of inter-tract correlations of population density functions of fractional anisotropy (FA).