Incidence Of Bone Metastases And Survival After A Diagnosis Of Bone Metastases (Bm) In Breast Cancer Patients

ABSTRACT Objectives To measure crude and cumulative incidence of BM and cumulative survival after diagnosis of BM. BM were grouped by (i) BM only (ii) BM followed by visceral metastases (iii) visceral metastases followed by BM. Methods Kaplan-Meier and Cox regression database analysis of women with breast cancer diagnosed 1975-2006 and treated at Guys Hospital London, whose details were prospectively updated regularly till end 2010. Results Of 7064 women, 1589 (22%) developed BM by end follow-up (mean 8.4 years); 2254 (32%) were diagnosed with breast cancer Conclusion Incidence of BM has decreased in recent years and risk of BM is significantly affected by clinical tumour characteristics. Women with bone only metastases survive longer with their disease. BM remain an important target for prevention, treatment and palliation in breast cancer. Disclosure A. Taylor: I own shares with Amgen and work at Amgen. All other authors have declared no conflicts of interest.