Preparation Of Indomethacin Solid Dispersions By Mechanochemical Technology And The Characterization

Solid dispersions (SDs) of indomethacin (IMC) with different excipients were prepared by mechanical ball milling to improve the solubility and dissolution rate of IMC. The SDs of IMC was characterized by differential scanning calorimetry, X-ray diffraction, fourier transform infrared spectroscopy. In addition, the solubility, dissolution rate and stability tests were also carried out to evaluate the SDs of IMC. The results showed that IMC was in an amorphous state and uniformly dispersed in SD. Meanwhile, the solubility and dissolution rate of IMC in SDs were significantly improved and hydroxypropyl methylcellulose acetate succinate was selected as optimal excipients to prepare SDs of IMC.