Preventive Effects And Nursing Values Of Two Cu(Ii) Coordination Polymers On Stress Response And Pain In Glaucoma Surgery

In the current study, via using the mixed-ligand synthesis approach, two new transition metal coordination polymers (CPs), namely, [Cu-3(tit)(2)(2,6-ndc)(2)(H2O)(2)]center dot 2NO(3)center dot 2H(2)O (2, 2,6-H(2)ndc = 2,6-naphthalenedicarboxylic acid) and [Cu(tib)(1,4-ndc)]center dot 2DMF (1, 1,4-H(2)ndc = 1,4-naphthalenedicarboxylic acid), were fabricated based on 1,3,5-tris(1-imidazolyl)benzene (tib), 2,4,6-tri(1H-imidazol-1-yl)-1,3,5-triazine (tit) and diverse carboxylic acid ligands. Furthermore, the preventive effects and nursing values of compounds 1 and 2 on stress response and pain in glaucoma surgery was assessed, and the correlative mechanism was discussed simultaneously. Firstly, the ELISA test assay was utilized to determine the acetylcholine content in synaptic cleft after compounds' treatment. In addition to this, we conducted hot plate analgesia experiment and determined the pain threshold in mice.