Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing
Michael O. Frederick, Raymond A. Boyse,Timothy M. Braden,Joel R. Calvin,Bradley M. Campbell,Shujauddin M. Changi, Stephanie R. Coffin, Carmel Condon,Olivia Gowran,Jennifer McClary Groh,Stephen R. Groskreutz,Zachary D. Harms, Ashley A. Humenik,Neil J. Kallman, Nicholas D. Klitzing,Michael E. Kopach,Juliana K. Kretsinger,Gordon R. Lambertus, Jeffrey T. Lampert, Laura M. Maguire,Humphrey A. Moynihan, Nessa S. Mullane,John D. Murphy, Marie E. O'Mahony,Rachel N. Richey,Kevin D. Seibert,Richard D. Spencer,Mark A. Strege,Nil Tandogan, Torres,Sergey Tsukanov,Han Xia Organic Process Research & Development（2021）
关键词
tirzepatide,hybrid SPPS/LPPS synthesis,synthetic peptide,nanofiltration
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