Convenient Synthesis of Some New Thiophene, Pyrazole, and Thiazole Derivatives Bearing Biologically Active Sulfonyl Guanidine Moiety

The synthesis and characterization of a variety of novel heterocyclic compounds bearing the pharmacophore N-carbamimidoylsulfamoyl moiety that are relevant to antibacterial and antifungal activities are described. All the newly synthesized compounds have been characterized on the basis of IR, H-1 MR and C-13 NMR spectral data as well as physical data. The synthesized compounds, except thiophene 10, were tested against six standard microbial pathogens, and the antimicrobial activity of these compounds was evaluated according to the microdilution method. Most of the newly tested derivatives showed good to excellent antimicrobial activity when applied to MIC/MBC and MIC/MFC values.