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Pomegranate (Punica granatum) extract and its polyphenols reduce the formation of methylglyoxal-DNA adducts and protect human keratinocytes against methylglyoxal-induced oxidative stress

Hao Guo,Chang Liu,Qi Tang,Deyu Li,Yinsheng Wan,Jiu-Hong Li,Xing-Hua Gao,Navindra P. Seeram,Hang Ma,Hong-Duo Chen

Journal of Functional Foods（2021）

Cited 3|Views7
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Abstract
•Pomegranate extract and punicalagin reduce MGO-induced DNA adducts.•Pomegranate extract and punicalagin reduce MGO-induced cellular DNA damage.•Pomegranate extract and punicalagin alleviate MGO-induced keratinocyte toxicity.•Pomegranate extract and punicalagin promote skin cell adhesion and migration.•Pomegranate extract and punicalagin enhance wound healing rate.
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Key words
Pomegranate (Punica granatum),Punicalagin,Methylglyoxal,DNA damage,Wound healing,Skin protection
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