Effects Of Different Categories Of Female Chromosomal Polymorphisms On Outcomes Of Ivf-Et Cycles

OBJECTIVE: To determine whether different categories of female chromosomal polymorphisms could affect the outcomes of in vitro fertilization-embryo transfer (IVF-ET).STUDY DESIGN: We retrospectively analyzed data from 4,349 infertile couples and selected 168 with the following female karyotypes: 52 with qh+ (group 1), 31 with inv(9)(p12q13) (group 2), 85 with D/G genome variation (group 3), and 269 with normal karyotypes (control; group 4). We then compared the clinical outcomes of IVF and ET among the groups.RESULTS: The most frequent chromosomal polymorphisms were 1qh+ (1.17%), inv(9)(p12q13) (1.03%), and 21pstk+ (0.87%). Embryo cleavage rates were significantly lower in groups 1 and 3 as compared with those in the control group (98.53% vs. 99.46%, p= 0.037; 98.27% vs. 99.46%, p=0.002, respectively). Clinical pregnancy rates were significantly lower in group 1 as compared with those in the control group (33.33% vs. 51.00%, p=0.025). Binary logistic regression analysis showed that group 1 had lower rates of clinical pregnancy and live births than did the control group (odds ratio (OR) =0.432, p=0.016; OR=0.468, p=0.046, respectively).CONCLUSION: Polymorphic variations in female qh+ and D/G adversely influence IVF-ET outcomes.