Determination of major radionuclidic impurities in K 99 TcO 4 pharmaceutical raw material

A rapid analytical method for sequential separation and determination of the most significant α- and β-emitting radionuclidic impurities in 99 Tc radiopharmaceutical raw material is presented. Successive HTiO co-precipitation steps were first conducted for effective removal of 99 Tc to avoid its spectral interference on the determination of β-emitting nuclides by liquid scintillation counting. A sequential chromatographic method was applied for simultaneous separation and purification of actinide and lanthanide isotopes. A series of K 99 TcO 4 solution spiked with known quantities of 238 Pu, 239 Pu, 241 Pu, 237 Np, 241 Am, 244 Cm and 147 Pm were analyzed for method evaluation, demonstrating that the method would meet the analytical requirements for radionuclidic impurity evaluation of K 99 TcO 4 raw material.