Mechanisms Of Morphology Death Of Tumor Cell By Effect Non-Radioactive And Radioactive Pt-195m-Cisplatin

The photonuclear technology of preparation radioactive cisplatin Pt-195m was been developed by the bremsstrahlung from the electron accelerators. In the novel technology, the production of Pt-195m from reaction Au-197(gamma,np)Pt-195m with a high specific activity >1 Ci/mg(-1) was realized. The Ehrlich adenocarcinoma cells were been used as a neoplastic model. There are two groups: 1. tumor cells with non-radioactive cisplatin; 2. tumor cells with radioactive cisplatin (0.17 pg Pt-195m-cisplatin). The number of morphology death cells as a result of radioactive cisplatin action was more than after action of non-radioactive cisplatin. The different mechanisms of the morphology death cell (necrosis for non-radioactive and apoptosis for radioactive) were detected.