89 Zr as a promising radionuclide and it’s applications for effective cancer imaging

Molecular imaging using PET plays an important role for the diagnosis of different diseases. Immuno-PET combines the utilization of PET radionuclides and antibodies/proteins/peptides, presenting a popular method for imaging of different diseases, including cancer. 89 Zr is an attractive radiometal for immuno-PET but far from ideal due to its high radiation dose for the patients. However, its long half-life is sometimes advantageous and suitable for labelling antibodies, proteins and other biomolecules. This review compiles opportunities and applications for using 89 Zr in preclinical and clinical practice. It contains either results from for its production, preclinical and clinical studies.