The rate of aneuploidy and chance of having at least one euploid tested embryo per ivf cycle in 21,493 preimplantation genetic screening for aneuploidy (pgt-a) tested embryos as determined by a large genetic laboratory

ObjectiveTo evaluate the rate of aneuploidy and euploidy in PGT-A tested embryos and the chance of having at least one normal PGT-A embryo available per IVF cycle as determined by a large data set taken from a central genetics laboratory.Materials and MethodsThis is a single-center retrospective cohort study. Ploidy results from all embryos that underwent PGT-A at a large central genetics laboratory were retrospectively evaluated from the years 2014 to 2019. This yielded data from 24,084 embryos generated from 4,833 individual IVF cycles and 57 fertility clinics. Data was then organized based on the SART age grouping and evaluated. IVF results from embryos containing indeterminate data in which a clear PGT-A diagnosis was not achieved were then excluded from the analysis.ResultsOf the initial 24,084 embryos evaluated, a complete PGT-A genotype was present in 23,561 (97.8%) of embryos. Of these 23,561 total embryos, 12,875 (53.4%) were aneuploid and 10,686 (44.4%) were euploid. Aneuploidy rate as evaluated by SART age groupings were as follows: age <35 (46%), age 35-37 (54%), age 38-40 (63%), age 41-42 (66%), and age >42 (54%). Of all 4,833 IVF cycles evaluated, 3,675 (76%) had at least one embryo with a normal PGT-A result. As evaluated by SART age groupings, the chance of having least one embryo with a normal PGT-A result per IVF cycle were as follows: age <35 (86%), age 35-37 (81%), age 38-40 (70%), age 41-42 (56%), and age >42 (64%).ConclusionsThis large data set supports the phenomenon that embryonic aneuploidy dramatically increases with advancing maternal age. However, this data also is encouraging for couples undergoing an IVF cycle with PGT-A as the vast majority of women even in the older demographics had at least one PGT-A normal embryo available. Certainly, this data could be used to help better counsel patients considering IVF with PGT-A.Financial SupportNone ObjectiveTo evaluate the rate of aneuploidy and euploidy in PGT-A tested embryos and the chance of having at least one normal PGT-A embryo available per IVF cycle as determined by a large data set taken from a central genetics laboratory. To evaluate the rate of aneuploidy and euploidy in PGT-A tested embryos and the chance of having at least one normal PGT-A embryo available per IVF cycle as determined by a large data set taken from a central genetics laboratory. Materials and MethodsThis is a single-center retrospective cohort study. Ploidy results from all embryos that underwent PGT-A at a large central genetics laboratory were retrospectively evaluated from the years 2014 to 2019. This yielded data from 24,084 embryos generated from 4,833 individual IVF cycles and 57 fertility clinics. Data was then organized based on the SART age grouping and evaluated. IVF results from embryos containing indeterminate data in which a clear PGT-A diagnosis was not achieved were then excluded from the analysis. This is a single-center retrospective cohort study. Ploidy results from all embryos that underwent PGT-A at a large central genetics laboratory were retrospectively evaluated from the years 2014 to 2019. This yielded data from 24,084 embryos generated from 4,833 individual IVF cycles and 57 fertility clinics. Data was then organized based on the SART age grouping and evaluated. IVF results from embryos containing indeterminate data in which a clear PGT-A diagnosis was not achieved were then excluded from the analysis. ResultsOf the initial 24,084 embryos evaluated, a complete PGT-A genotype was present in 23,561 (97.8%) of embryos. Of these 23,561 total embryos, 12,875 (53.4%) were aneuploid and 10,686 (44.4%) were euploid. Aneuploidy rate as evaluated by SART age groupings were as follows: age <35 (46%), age 35-37 (54%), age 38-40 (63%), age 41-42 (66%), and age >42 (54%). Of all 4,833 IVF cycles evaluated, 3,675 (76%) had at least one embryo with a normal PGT-A result. As evaluated by SART age groupings, the chance of having least one embryo with a normal PGT-A result per IVF cycle were as follows: age <35 (86%), age 35-37 (81%), age 38-40 (70%), age 41-42 (56%), and age >42 (64%). Of the initial 24,084 embryos evaluated, a complete PGT-A genotype was present in 23,561 (97.8%) of embryos. Of these 23,561 total embryos, 12,875 (53.4%) were aneuploid and 10,686 (44.4%) were euploid. Aneuploidy rate as evaluated by SART age groupings were as follows: age <35 (46%), age 35-37 (54%), age 38-40 (63%), age 41-42 (66%), and age >42 (54%). Of all 4,833 IVF cycles evaluated, 3,675 (76%) had at least one embryo with a normal PGT-A result. As evaluated by SART age groupings, the chance of having least one embryo with a normal PGT-A result per IVF cycle were as follows: age <35 (86%), age 35-37 (81%), age 38-40 (70%), age 41-42 (56%), and age >42 (64%). ConclusionsThis large data set supports the phenomenon that embryonic aneuploidy dramatically increases with advancing maternal age. However, this data also is encouraging for couples undergoing an IVF cycle with PGT-A as the vast majority of women even in the older demographics had at least one PGT-A normal embryo available. Certainly, this data could be used to help better counsel patients considering IVF with PGT-A. This large data set supports the phenomenon that embryonic aneuploidy dramatically increases with advancing maternal age. However, this data also is encouraging for couples undergoing an IVF cycle with PGT-A as the vast majority of women even in the older demographics had at least one PGT-A normal embryo available. Certainly, this data could be used to help better counsel patients considering IVF with PGT-A.