Fucoxanthin alleviates methamphetamine-induced neurotoxicity possibly via the inhibition of interaction between Keap1 and Nrf2
Journal of Functional Foods(2021)
Abstract
•• Fucoxanthin inhibits methamphetamine-induced neuronal apoptosis and oxidative stress.•• Fucoxanthin promotes Nrf2 translocation via the activation of the Akt pathway.•• Fucoxanthin prevents Nrf2 degradation possibly via inhibiting Keap1-Nrf2 interaction.•• Fucoxanthin as a functional natural food for treating methamphetamine abuse.
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Key words
Fucoxanthin,Methamphetamine,Nrf2,Keap1,Oxidative stress,HO-1
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