Fucoxanthin alleviates methamphetamine-induced neurotoxicity possibly via the inhibition of interaction between Keap1 and Nrf2

•• Fucoxanthin inhibits methamphetamine-induced neuronal apoptosis and oxidative stress.•• Fucoxanthin promotes Nrf2 translocation via the activation of the Akt pathway.•• Fucoxanthin prevents Nrf2 degradation possibly via inhibiting Keap1-Nrf2 interaction.•• Fucoxanthin as a functional natural food for treating methamphetamine abuse.