Effects Of Kpna7 Gene Polymorphisms On Reproductive Traits In France Large White Pigs

KPNA7 is an essential nuclear protein for early embryogenesis and normal fertility. The aim of our study was to determine the associations between single nucleotide polymorphisms (SNPs) in the KPNA7 gene and the reproductive traits in France Large White pigs. Six new SNPs were identified by sequencing. Sows with CT genotype of rs81308652 had a significantly higher total number born than sows with CC and TT genotype in first parity. Litters from sows with TT genotype of rs81308652 had a significantly lower number of weak births than litters from sows with CC and CT genotype in multi parity. Individuals with GG genotype of rs327848277 showed higher litter weight at birth (LWB) and number of healthy births than individuals with genotype GT and TT in first parity, and individuals with genotype GG had lower LWB compared to other genotypes in multi parity. However, we obtained no statistically significant results for association between the SNPs in other four loci and reproductive traits in both primiparous and multiparous pigs. In conclusion, our results show that there are significant association of identified SNPs located in KPNA7 gene with pig reproductive traits, and provided a theoretical basis for genetic improvement of pig reproductive traits.