Synthesis of Indoline-Fused 2,5-Diketopiperazine Scaffolds via Ugi-4CR in the Basic Mediated Tandem Consecutive Cyclization

ADVANCED SYNTHESIS & CATALYSIS(2021)

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Abstract
This study has developed a method to prepare diastereo- and regio-selective indoline-fused 2,5-diketopiperazine scaffolds. The synthetic process involved an Ugi four-component reaction in which readily available starting materials were used and a metal-free intramolecular post-Ugi tandem consecutive 5-exo-trig/6-exo-dig cyclization under basic conditions. The plausible mechanism and substrate structures were elucidated by single-crystal X-ray diffraction analysis and supported by density functional theory calculations.
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Key words
Cyclization, 2, 5-Diketopiperazine, Indoline-fused 2, 5-Diketopiperazine, Multicomponent reactions, Ugi-4CR, Post-Ugi transformation
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