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Synthesis and BK channel-opening activity of 2-amino-1,3-thiazole derivatives

Xiao-Lei Qi,Heeji Jo,Xue-Ying Wang, Tong-Tong Ji,Hai-Xia Lin,Chul-Seung Park,Yong-Mei Cui

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2021）

Cited 2|Views18
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Abstract
A series of 2-amino-5-arylmethyl-or 5-heteroarylmethyl-1,3-thiazole derivatives were synthesized and evaluated for BK channel-opening activities in cell-based fluorescence assay and electrophysiological recording. The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at benzene ring.
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Key words
BK channels,Openers,Synthesis,Thiazole,SAR
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