Potentiometric Multisensory System Based on MF-4SC Membranes and Surface Modified Oxides for Analysis of Nicotinic Acid Pharmaceuticals

Hybrid materials based on MF-4SC perfluorosulfonic acid membranes have been studied as materials of potentiometric sensors for the determination of nicotinic acid in aqueous solutions and pharmaceuticals. The hybrid membranes contained incorporated nanoparticles of zirconia and silica with a sulfonated (directly or via hydrocarbon groups) surface (MF-4SC/ZrO 2 – SO_3^ - , MF-4SC/SiO 2 –(CH 2 ) 3 – SO_3^ - ) and nanoparticles of silica modified with 3-aminopropyl (MF-4SC/SiO 2 –(CH 2 ) 3 – NH_3^ + ). The relationships between the nature, concentration of dopant, transport properties of materials, and characteristics of sensors based on them have been established. The limits of detection of nicotinic acid ions in the aqueous solutions have been found to be 10 –8 –10 –7 М. The array of cross-sensitive sensors based on membranes containing 5 wt