Solubility Behavior Of L-Homophenylalanine Ethyl Ester Hydrochloride In 12 Individual Solvents From 283.15 To 323.15 K

The mole fraction solubility data of L-homophenylalanine ethyl ester hydrochloride in 12 neat solvents (ethanol, npropanol, i-propanol, n-butanol, i-butanol, s-butanol, n-pentanol, acetone, 1,4-dioxane, 2-butanone, dichloromethane, and methyl acetate) were determined by the static gravimetric method within the temperature range from 283.15 to 323.15 K under the ambient pressure of 98.8 kPa. Analysis of the neat solvents data showed that the solubility behavior was influenced by the molecular structure, molecular steric hindrance, polarity, hydrogen bond, cohesive energy density, and so on. Two thermodynamic models, i.e., the modified Apelblat model and the Yaws model were used to correlate the solubility data. To evaluate the fitting results, the average relative deviations, root mean square deviations, Akaike information criterion, and Akaike weights were calculated.