Wearable biomolecule smart sensor based on Au@PB NPs with high electrochemical activity

•Core-shell structural Au@PB NPs were prepared, which shown highly electrochemical activity with rate constants (Кs) 600 S−1.•One-step synthesis of low-cost, high-performance mixed ink as sensor working electrode.•Au@PB NPs-based flexible biosensor exhibits excellent performance for detection of biomarkers, such as H2O2 and glucose.•As-prepared enzyme glove sensor displayed promising potential for fabrication of wearable sensor for glucose monitoring.