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Dietary supplementation of camel whey protein attenuates heat stress-induced liver injury by inhibiting NLRP3 inflammasome activation through the HMGB1/RAGE signalling pathway

Donghua Du,Wenting Lv,Xiaoxia Jing,Xueni Ma,Jiya Wuen,Surong Hasi

Journal of Functional Foods（2021）

Cited 4|Views1
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Abstract
•The HMGB1/RAGE/NLRP3 signaling pathway is involved in HS-induced liver injury.•CWP inhibited HS-induced liver injury by reducing activity of the NLRP3 inflammasome.•CWP inhibited the activation of NLRP3 inflammasome by restoring HMGB1 nuclear localization.•The combined application of CWP and anti-inflammatory agent completely blocked HS-induced liver injury.
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Key words
Heat stress,Liver injury,Camel whey protein,NLRP3,HMGB1
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