Use of eltrombopag and granulocyte-colony stimulating-factor in treatment of lomustine overdose in a dog

An 8-year-old male neutered golden retriever diagnosed with a T-cell lymphoma and treated with a modified LOPP (lomustine, vincristine, prednisolone and procarbazine) protocol was presented to a referral hospital for management of an accidental overdose of lomustine (180 mg/m(2)). This overdose resulted in a severe myelosuppression with neutropenia and thrombocytopenia. The human platelet stimulator eltrombopag was used as part of the treatment protocol, alongside granulocyte-macrophage colony-stimulating factor and supportive care. The dog made a good recovery and completed a course of chemotherapy, achieving complete clinical remission of the lymphoma and long-term survival (613 days).