The Absence of Syndecan-1 Leads to More Inflammation in the Mouse Model of Rheumatoid Arthritis

Syndecan‐1 (sdc‐1) is a member of a family of transmembrane proteoglycans expressed in numerous cell types. It has been shown to be involved in carcinogenesis, wound healing and inflammation. However, its potential role in the pathophysiology of Rheumatoid Arthritis (RA) has not been well elucidated yet. Many modified mouse strains are relatively resistant to collagen‐induced RA, while others could acquire it spontaneously. Such strains have been very useful for assessing therapeutics with anti‐inflammatory properties.