Biodegradable Microparticles for Bone Tissue Regeneration Based on Polylactide and Hydroxyapatite Nanoparticles

The process of forming hybrid microparticles from a biodegradable polyester, that is, polylactide, and hydroxyapatite nanoparticles, which can be promising as cellular microcarriers or starting materials for obtaining three-dimensional scaffolds for bone tissue regeneration, has been investigated. A method has been developed for fabricating hybrid microparticles by evaporation of solvents from oil/water emulsions without the use of additional emulsifiers in a dispersion phase. It is shown that hydroxyapatite nanoparticles can effectively stabilize the interface during the preparation of microparticles. The effect of the concentration of hydroxyapatite nanoparticles and their preliminary dispersion using ultrasonic treatment on the yield of microparticles, their size distribution and morphology was evaluated.