24988 Spectrum of facial angiofibromas in 85 patients with tuberous sclerosis complex in a tertiary hospital. Retrospective study and revision of the literature

Background: Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by multiple hamartomas in different organs. Classic triad, found exclusively in 29% of patients, involves facial angiofibromas, mental retardation, and epilepsy. Dermatologic manifestations appear in 90% of patients, including facial angiofibromas, fibrous cephalic plaques, hypomelanotic macules, Koebner tumours, and shagreen patches.