Changes in Point of Maximal Curvature During Collagenase Clostridium Histolyticum Injections for Peyronie's Disease

OBJECTIVE To determine change in the point of maximal curvature (POMC) during Collagenase Clostridium histolyticum (CCH) injections for Peyronie's disease (PD). METHODS A prospective database has been maintained of all men undergoing CCH injections since March 2014. For the current study, data were abstracted on the POMC with each curve assessment and correlated with demographic and clinical factors. Maximal changes were defined as the largest change in POMC from baseline. RESULTS Six hundred and eighteen men underwent >= 1 series of CCH, with 313 having a baseline and subsequent POMC measurements available. Median baseline curvature was 60.0 degrees and POMC 2.8 cm. Among 189 men who were satisfied or completed 8 CCH injections, the median improvement in penile curvature was -27.5 degrees (40.9%). The median maximal change in POMC during CCH treatment was 1.0 cm (interquartile range, 0.5, 1.8). Overall, 55.6% had changes in POMC of >= 1 cm, 23.6% >= 2 cm, 8.9% >= 3 cm, and 3.8% >= 4 cm. Multivariate logistic regression identified ventral curvature as a predictor of larger change in POMC, after controlling for other variables. Study limitations included the observational, non-randomized study design and potential for intra- and inter-individual measurement variability. Strengths are the inclusion of an all-comer population, large series, prospective database, and routine objective assessments. CONCLUSION Approximately half of men with PD undergoing CCH experience >= 1 cm of change in POMC during the treatment course, with nearly 1/4 experiencing >= 2 cm. Findings suggest that patients may benefit from repeat curvature assessments with each CCH series to optimize accuracy of drug administration. UROLOGY 184: 122-127, 2024. (c) 2023 Published by Elsevier Inc.