Multiple Physically Cross-Linked F127-Alpha-Cd Hydrogels: Preparation, Sol-Gel Transformation, And Controlled Release Of 5-Fluorouracil

Pluronic F127 is a thermosensitive polymer that has been extensively studied and utilized in biomedicine. To improve the gelation properties of F127, alpha-cyclodextrin was introduced by physical interactions, such as forming inclusion complexes, hydrogen bond self-assembly, and hydrophobic interactions, to prepare F127-alpha-CD hydrogels. This study explored the temperature-dependent sol-gel transition behavior, gelation mechanism, interior morphology, and controlled release of the anticancer drug 5-fluorouracil. Results showed that hydrogel could be obtained at 1.0%-8.0% weight content of F127. The cross-linking points in this system were PEO-alpha-CD microcrystalline region and micelle with poly(propylene oxide) as the core. The network inside F127-alpha-CD hydrogels made it stable and conducive for controlled release. Therefore, this hydrogel is a promising drug release system.